ID   SHMOS_HUMAN             Reviewed;          58 AA.
AC   C0HM83;
DT   08-NOV-2023, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2023, sequence version 1.
DT   09-APR-2025, entry version 6.
DE   RecName: Full=Protein SHMOOSE {ECO:0000303|PubMed:36127429};
DE   AltName: Full=Small human mitochondrial ORF over serine tRNA {ECO:0000303|PubMed:36127429};
OS   Homo sapiens (Human).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7219534; DOI=10.1038/290457a0;
RA   Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R.,
RA   Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H.,
RA   Smith A.J.H., Staden R., Young I.G.;
RT   "Sequence and organization of the human mitochondrial genome.";
RL   Nature 290:457-465(1981).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 15-25 AND 42-58, FUNCTION, INTERACTION WITH IMMT,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ASN-47, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=36127429; DOI=10.1038/s41380-022-01769-3;
RG   Alzheimer's Disease Neuroimaging Initiative;
RA   Miller B., Kim S.J., Mehta H.H., Cao K., Kumagai H., Thumaty N.,
RA   Leelaprachakul N., Braniff R.G., Jiao H., Vaughan J., Diedrich J.,
RA   Saghatelian A., Arpawong T.E., Crimmins E.M., Ertekin-Taner N., Tubi M.A.,
RA   Hare E.T., Braskie M.N., Decarie-Spain L., Kanoski S.E., Grodstein F.,
RA   Bennett D.A., Zhao L., Toga A.W., Wan J., Yen K., Cohen P.;
RT   "Mitochondrial DNA variation in Alzheimer's disease reveals a unique
RT   microprotein called SHMOOSE.";
RL   Mol. Psychiatry 28:1813-1826(2023).
RN   [3] {ECO:0000305}
RP   ERRATUM OF PUBMED:36127429.
RX   PubMed=36658336; DOI=10.1038/s41380-023-01956-w;
RG   Alzheimer's Disease Neuroimaging Initiative;
RA   Miller B., Kim S.J., Mehta H.H., Cao K., Kumagai H., Thumaty N.,
RA   Leelaprachakul N., Braniff R.G., Jiao H., Vaughan J., Diedrich J.,
RA   Saghatelian A., Arpawong T.E., Crimmins E.M., Ertekin-Taner N., Tubi M.A.,
RA   Hare E.T., Braskie M.N., Decarie-Spain L., Kanoski S.E., Grodstein F.,
RA   Bennett D.A., Zhao L., Toga A.W., Wan J., Yen K., Cohen P.;
RL   Mol. Psychiatry 28:1827-1827(2023).
CC   -!- FUNCTION: Increases neural cell metabolic activity and mitochondrial
CC       oxygen consumption rate. {ECO:0000269|PubMed:36127429}.
CC   -!- SUBUNIT: Interacts with IMMT/mitofilin. {ECO:0000269|PubMed:36127429}.
CC   -!- INTERACTION:
CC       C0HM83; Q16891: IMMT; NbExp=5; IntAct=EBI-46442350, EBI-473801;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:36127429}.
CC       Nucleus {ECO:0000269|PubMed:36127429}. Note=Detected in neuronal
CC       mitochondria and nuclei. {ECO:0000269|PubMed:36127429}.
CC   -!- TISSUE SPECIFICITY: Detected in cerebrospinal fluid (at protein level).
CC       {ECO:0000269|PubMed:36127429}.
CC   -!- MISCELLANEOUS: Shows elevated expression in Alzheimer disease patient
CC       brains and protects against cell death in vitro in neuronal cells
CC       stressed with oligomerized amyloid-beta protein 42.
CC       {ECO:0000269|PubMed:36127429}.
CC   -!- MISCELLANEOUS: Intracerebroventricular administration to the rat brain
CC       for 24 hours results in significant alterations to the hypothalamus
CC       transcriptome and, to a lesser extent, the hippocampus transcriptome.
CC       {ECO:0000269|PubMed:36127429}.
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DR   EMBL; J01415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IntAct; C0HM83; 1.
DR   Proteomes; UP000005640; Mitochondrion MT.
DR   GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   Pfam; PF23661; SHMOOSE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mitochondrion; Nucleus; Reference proteome.
FT   CHAIN           1..58
FT                   /note="Protein SHMOOSE"
FT                   /id="PRO_0000458864"
FT   REGION          27..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..45
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..58
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         47
FT                   /note="D -> N (risk factor for Alzheimer disease; protein
FT                   does not protect against cell death in vitro in neuronal
FT                   cells stressed with oligomerized amyloid-beta protein 42;
FT                   dbSNP:rs2853499)"
FT                   /evidence="ECO:0000269|PubMed:36127429"
FT                   /id="VAR_088368"
SQ   SEQUENCE   58 AA;  6637 MW;  961C5C3F9CF34204 CRC64;
     MPPCLTTWLS QLLKDNSYPL VLGPKNFGAT PNKSNNHAHY YNHPNPDFPN SPHPYHPR
//